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Related Papers - Brain

Brain- Hyperbaric Oxygen Therapy Improves Parkinson’s Disease



Hyperbaric Oxygen Therapy Improves Parkinson’s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway
HBOT activates the SIRT-1/PGC-1α axis, boosting mitochondrial biogenesis, damping inflammation, and restoring motor function in Parkinson’s disease models.
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What Did They Discover?
In a toxin-induced Parkinson’s model, HBOT preserved tyrosine hydroxylase–positive dopaminergic neurons in the substantia nigra and improved movement tests (distance, speed, grip, rotarod). Cellular assays showed longer neurites and healthier morphology, indicating functional rescue beyond lab markers.
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How Does It Work?
HBOT upregulated SIRT-1, PGC-1α, and TFAM—keys that “switch on” mitochondrial production—along with VDAC, signaling more and better power plants inside neurons. In parallel, it reduced NF-κB–driven inflammatory proteins (COX-2, iNOS, TNF-α) and limited apoptosis markers (Bax/Bcl-2 ratio, cytochrome c, cleaved caspase-3).
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Why Does It Matter?
Parkinson’s symptoms track closely with mitochondrial failure and neuroinflammation; HBOT targets both levers at once. By rebuilding energy capacity and quieting toxic signals, it supports the circuits that govern movement—like fixing the engine and the wiring together.

Key Mechanisms

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Deep-sleep PBM amplifies glymphatic flow
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Light boosts NO and blood circulation
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Amyloid-beta clearance and neuron protection
Conclusion
HBOT rebuilds neuronal energy and calms damaging signals, translating into clearer motor gains.