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Related Papers - Brain

Brain- Molecular Hydrogen as a Neuroprotective Agent



Molecular Hydrogen as a Neuroprotective Agent_eng
Conclusion
  • The study examined the neuroprotective effects of hydrogen (H₂) therapy in animal models and human clinical studies experiencing neurodegenerative damage induced by oxidative stress.
  • Hydrogen was administered through three routes: H₂ gas inhalation, ingestion of H₂-dissolved water, and injection of H₂-dissolved saline, exerting its effects primarily by selectively reducing highly toxic reactive oxygen radicals (·OH) and peroxynitrite.
  • Hydrogen therapy significantly reduced oxidative stress and inflammation in cerebral ischemia–reperfusion injury (IRI) and other neurodegenerative disorders, demonstrating neuroprotective effects (p < 0.05) and being proposed as a clinically safe and effective therapeutic alternative.